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Ingels, Alexandre; Ploussard, Guillaume; Allory, Yves; Abbou, Claude; de la Taille, Alexandre; Salomon, Laurent

Concomitant High-Grade Prostatic Intraepithelial Neoplasia Is Associated with Good Prognosis Factors and Oncologic Outcome after Radical Prostatectomy

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  • Medientyp: E-Artikel
  • Titel: Concomitant High-Grade Prostatic Intraepithelial Neoplasia Is Associated with Good Prognosis Factors and Oncologic Outcome after Radical Prostatectomy
  • Beteiligte: Ingels, Alexandre; Ploussard, Guillaume; Allory, Yves; Abbou, Claude; de la Taille, Alexandre; Salomon, Laurent
  • Erschienen: S. Karger AG, 2014
  • Erschienen in: Urologia Internationalis
  • Sprache: Englisch
  • DOI: 10.1159/000351319
  • ISSN: 0042-1138; 1423-0399
  • Schlagwörter: Urology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; To assess correlations between concomitant high-grade prostatic intraepithelial neoplasia (HGPIN), pathological features and oncologic outcomes after radical prostatectomy (RP). &lt;b&gt;&lt;i&gt;Material and Methods:&lt;/i&gt;&lt;/b&gt; We prospectively collected a single-institution database of 2,351 patients who underwent RP between 1998 and 2011. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; 1,272 (54.1%) patients had HGPIN on specimens. The mean follow-up was 28 months. Presence of HGPIN was significantly associated with a favorable preoperative risk status and with pathological factors of poor prognosis in RP specimens. Patients without HGPIN had a worse biochemical recurrence-free survival compared with those with HGPIN in RP specimen (log-rank test: p = 0.015). The 3-year RFS rate was 73.9% for the HGPIN group versus 67.2%. The absence of HGPIN was also significantly correlated with the use of androgen deprivation treatment during the follow-up (p &lt; 0.001). In Cox multivariate analysis, taking into account the other prognostic pathological factors, HGPIN was not an independent predictive factor for PSA failure (p = 0.868). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; HGPIN is associated with factors of good prognosis but fails to show independent significance when classical pathological prognostic factors are taken into account.</jats:p>