Beschreibung:
<jats:p>
<jats:italic>Abstract</jats:italic>
Hyperinsulinemia reduces the vasoconstrictive response to norepinephrine in Wistar-Kyoto rats (WKY) but not in spontaneously hypertensive rats (SHR). It has been hypothesized that this difference in the vascular effect of insulin could be a hallmark of the hypertensive state. To test this hypothesis we studied SHR before (5 weeks old, n=10) and after (15 weeks old, n=10) the establishment of hypertension as well as two groups of age- and sex-matched WKY (5 weeks old, n=14; 15 weeks old, n=13). Blood pressure was significantly higher in SHR compared with WKY (181±5 versus 118±6 mm Hg, respectively,
<jats:italic>P</jats:italic>
<.001) in the 15-week-old rats but not in the 5-week-old rats (121±5 versus 117±3 mm Hg,
<jats:italic>P</jats:italic>
<NS). We tested vascular reactivity using increasing amounts of norepinephrine (from 10
<jats:sup>−10</jats:sup>
to 10
<jats:sup>−5</jats:sup>
mmol/L) on isolated aortic rings in control conditions and after 30 minutes of exposure to 715 pmol/L insulin. In WKY insulin reduced the vascular response to norepinephrine in both the 5-week-old (repeated-measures ANOVA with grouping factor: F=2.443,
<jats:italic>P</jats:italic>
<.05) and 15-week-old (F=9.667,
<jats:italic>P</jats:italic>
<.01) groups. In SHR at both ages insulin failed to modify the vascular response to norepinephrine (5 weeks: F=0.107,
<jats:italic>P</jats:italic>
<NS; 15 weeks: F=0.075,
<jats:italic>P</jats:italic>
<NS). Sodium nitroprusside was able to attenuate the vascular response to norepinephrine in WKY and SHR at 5 and 15 weeks. Our data demonstrate that in SHR the vascular resistance to insulin action is specific and not acquired with the hypertensive condition; thus, it seems to be a genetically inherited trait.
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