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Buyandelger, Byambajav; Mansfield, Catherine; Kostin, Sawa; Choi, Onjee; Roberts, Angharad M.; Ware, James S.; Mazzarotto, Francesco; Pesce, Francesco; Buchan, Rachel; Isaacson, Rivka L.; Vouffo, Josée; Gunkel, Sylvia; Knöll, Gudrun; McSweeney, Sara J.; Wei, Heming; Perrot, Andreas; Pfeiffer, Conny; Toliat, Mohammad Reza; Ilieva, Kristina; Krysztofinska, Ewelina; López-Olañeta, Marina M.; Gómez-Salinero, Jesús M.; Schmidt, Albrecht; Ng, Keat-Eng; [...]

ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

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  • Medientyp: E-Artikel
  • Titel: ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure
  • Beteiligte: Buyandelger, Byambajav; Mansfield, Catherine; Kostin, Sawa; Choi, Onjee; Roberts, Angharad M.; Ware, James S.; Mazzarotto, Francesco; Pesce, Francesco; Buchan, Rachel; Isaacson, Rivka L.; Vouffo, Josée; Gunkel, Sylvia; Knöll, Gudrun; McSweeney, Sara J.; Wei, Heming; Perrot, Andreas; Pfeiffer, Conny; Toliat, Mohammad Reza; Ilieva, Kristina; Krysztofinska, Ewelina; López-Olañeta, Marina M.; Gómez-Salinero, Jesús M.; Schmidt, Albrecht; Ng, Keat-Eng; [...]
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2015
  • Erschienen in: Circulation: Cardiovascular Genetics, 8 (2015) 5, Seite 643-652
  • Sprache: Englisch
  • DOI: 10.1161/circgenetics.113.000690
  • ISSN: 1942-325X; 1942-3268
  • Schlagwörter: Genetics (clinical) ; Cardiology and Cardiovascular Medicine ; Genetics
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec> <jats:title>Background—</jats:title> <jats:p>Mutations in sarcomeric and cytoskeletal proteins are a major cause of hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic defects execute their effects.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> We used cysteine and glycine-rich protein 3, a known cardiomyopathy gene, in a yeast 2-hybrid screen and identified zinc-finger and BTB domain-containing protein 17 ( <jats:italic>ZBTB17</jats:italic> ) as a novel interacting partner. <jats:italic>ZBTB17</jats:italic> is a transcription factor that contains the peak association signal (rs10927875) at the replicated 1p36 cardiomyopathy locus. <jats:italic>ZBTB17</jats:italic> expression protected cardiac myocytes from apoptosis in vitro and in a mouse model with cardiac myocyte–specific deletion of <jats:italic>Zbtb17</jats:italic> , which develops cardiomyopathy and fibrosis after biomechanical stress. <jats:italic>ZBTB17</jats:italic> also regulated cardiac myocyte hypertrophy in vitro and in vivo in a calcineurin-dependent manner. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> We revealed new functions for <jats:italic>ZBTB17</jats:italic> in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene. </jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang