Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women

Medientyp: E-Artikel
Titel: Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women
Beteiligte: Peters, Sanne A. E.; Yang, Ling; Guo, Yu; Chen, Yiping; Bian, Zheng; Du, Jianwei; Yang, Jie; Li, Shanpeng; Li, Liming; Woodward, Mark; Chen, Zhengming; Chen, Junshi; Collins, Rory; Peto, Richard; Bennett, Derrick; Chang, Yumei; Clarke, Robert; Du, Huaidong; Fan, Xuejuan; Gilbert, Simon; Hacker, Alex; Holmes, Michael; Iona, Andri; Kartsonaki, Christiana; [...]
Erschienen: Ovid Technologies (Wolters Kluwer Health), 2017
Erschienen in: Journal of the American Heart Association, 6 (2017) 6
Sprache: Englisch
DOI: 10.1161/jaha.117.006081
ISSN: 2047-9980
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Beschreibung: <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases ( <jats:styled-content style="fixed-case">CVDs</jats:styled-content> ) in later life. However, the evidence on the effects of <jats:styled-content style="fixed-case">CVD</jats:styled-content> is still inconsistent, especially in East Asians, in whom the frequency and duration of breastfeeding significantly differ from those in the West. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> In 2004–2008, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 to 79 years from 10 diverse regions across China. During 8 years of follow‐up, 16 671 incident cases of coronary heart disease and 23 983 cases of stroke were recorded among 289 573 women without prior <jats:styled-content style="fixed-case">CVD</jats:styled-content> at baseline. Cox regression yielded adjusted hazard ratios ( <jats:styled-content style="fixed-case">HR</jats:styled-content> s) and 95% <jats:styled-content style="fixed-case">CIs</jats:styled-content> for incident <jats:styled-content style="fixed-case">CVD</jats:styled-content> by breastfeeding. Overall, ≈99% of women had given birth, among whom 97% reported a history of breastfeeding, with a median duration of 12 months per child. Compared with parous women who had never breastfed, ever breastfeeding was associated with a significantly lower risk of <jats:styled-content style="fixed-case">CVD</jats:styled-content> , with adjusted <jats:styled-content style="fixed-case">HR</jats:styled-content> s of 0.91 (95% <jats:styled-content style="fixed-case">CI,</jats:styled-content> 0.84–0.99) for <jats:styled-content style="fixed-case">coronary heart disease</jats:styled-content> and 0.92 (95% CI, 0.85–0.99) for stroke. Women who had breastfed for ≥24 months had an 18% ( <jats:styled-content style="fixed-case">HR,</jats:styled-content> 0.82; 0.77–0.87) lower risk of <jats:styled-content style="fixed-case">coronary heart disease</jats:styled-content> and a 17% ( <jats:styled-content style="fixed-case">HR,</jats:styled-content> 0.83; 0.79–0.87) lower risk of stroke compared with women who had never breastfed. Among women who ever breastfed, each additional 6 months of breastfeeding per child was associated with an adjusted <jats:styled-content style="fixed-case">HR</jats:styled-content> of 0.96 (95% CI, 0.94–0.98) for <jats:styled-content style="fixed-case">coronary heart disease</jats:styled-content> and 0.97 (95% CI, 0.96–0.98) for stroke. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> Among Chinese women, a history of breastfeeding was associated with an ≈10% lower risk of <jats:styled-content style="fixed-case">CVD</jats:styled-content> in later life and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding. </jats:p> </jats:sec>
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