Beschreibung:
<jats:p>This study assessed the role of Curcumin in acute pulmonary embolism (APE) and inflammation. Male rats were assigned into sham operation group, APE group, low-dose and high-dose of Curcumin group for this study. Levels of IL-1<jats:italic>β</jats:italic>, TNF-<jats:italic>α</jats:italic>, and Interleukin-6 (IL-6)
inflammatory indicators were analyzed, including also, pathological changes of lung tissue. We also assessed High mobility group box 1 (HMGB1), receptor for advanced glycation end product (RAGE) and Nuclear factor kappa B (NF-<jats:italic>κ</jats:italic>B) protein expressions. Results showed that, inflammation
indicators were reduced after treatment at 6 h, 24 h, and 72 h, when compared with APE group, but were still higher than sham operation group (<jats:italic>P</jats:italic> <0.05). Serum inflammation index was higher at 2 h after modeling (<jats:italic>P</jats:italic> <0.05). Moreover, treatment groups showed continuously reduced
HMGB1 protein expression, with lower level of HMGB1 in high dose group (<jats:italic>P</jats:italic> <0.05). RAGE expression continued to increase in APE and treatment groups (<jats:italic>P</jats:italic> <0.05). However, its level in treatment groups was lower than APE group (<jats:italic>P</jats:italic> <0 05). The NF-KB expression continued
to increase in APE and treatment groups (<jats:italic>P</jats:italic> <0.05) with a lower level in treatment group (<jats:italic>P</jats:italic> <0.05). Curcumin effectively suppressed inflammatory response in acute pulmonary embolism, by reducing RAGE/NF-KB signal activity and inhibiting inflammatory response by inhibiting
HMGB1 expression.</jats:p>