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Papas, A.S.; Vollmer, W.M.; Gullion, C.M.; Bader, J.; Laws, R.; Fellows, J.; Hollis, J.F.; Maupomé, G.; Singh, M.L.; Snyder, J.; Blanchard, P.; White, Alex; Blanchard, Peter; Deane, Joy-Ann; Hamburger, Keith; Johnson, Joanne; Johnson, Kristen; Marangi-Marsden, Rosemary; Molina, Nydia; O’Connor, Kimberly; Tavano, Joanne; Torresyap, Gay; Maupome, Gerardo; Begay, Marilyn; [...]

Efficacy of Chlorhexidine Varnish for the Prevention of Adult Caries : A Randomized Trial

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  • Medientyp: E-Artikel
  • Titel: Efficacy of Chlorhexidine Varnish for the Prevention of Adult Caries : A Randomized Trial : A Randomized Trial
  • Beteiligte: Papas, A.S.; Vollmer, W.M.; Gullion, C.M.; Bader, J.; Laws, R.; Fellows, J.; Hollis, J.F.; Maupomé, G.; Singh, M.L.; Snyder, J.; Blanchard, P.; White, Alex; Blanchard, Peter; Deane, Joy-Ann; Hamburger, Keith; Johnson, Joanne; Johnson, Kristen; Marangi-Marsden, Rosemary; Molina, Nydia; O’Connor, Kimberly; Tavano, Joanne; Torresyap, Gay; Maupome, Gerardo; Begay, Marilyn; [...]
  • Erschienen: SAGE Publications, 2012
  • Erschienen in: Journal of Dental Research, 91 (2012) 2, Seite 150-155
  • Sprache: Englisch
  • DOI: 10.1177/0022034511424154
  • ISSN: 0022-0345; 1544-0591
  • Schlagwörter: General Dentistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX). We excluded participants for whom the study treatment was contraindicated or whose health might affect outcomes or ability to complete the study. Participants were randomly assigned to receive either the CHX coating (n = 490) or a placebo control (n = 493). Coatings were applied weekly for 4 weeks and a fifth time 6 months later. The primary outcome (total net D1-2FS increment) was the sum of weighted counts of changes in tooth surface status over 13 months. We observed no significant difference between the two treatment arms in either the intention-to-treat or per-protocol analyses. Analysis of 3 protocol-specified secondary outcomes produced similar findings. This trial failed to find that 10% (w/v) chlorhexidine diacetate coating was superior to placebo coating for the prevention of new caries ( Clinicaltrials.gov registration number NCT00357877).