Pscheidl, Edgar;
Hedwig‐Geissing, Monika;
Winzer, Cornelia;
Richter, Sabine;
Rügheimer, Erich
Effects of Chemically Defined Structured Lipid Emulsions on Reticuloendothelial System Function and Morphology of Liver and Lung in a Continuous Low‐Dose Endotoxin Rat Model
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Titel:
Effects of Chemically Defined Structured Lipid Emulsions on Reticuloendothelial System Function and Morphology of Liver and Lung in a Continuous Low‐Dose Endotoxin Rat Model
Beschreibung:
<jats:p><jats:italic>Background</jats:italic>: This study was undertaken to determine the effect of chemically defined structured lipids on nonspecific host defense and on histologic patterns of liver and lungs compared with a physical mixture of long‐chain triglycerides and medium‐chain triglycerides in a continuous low‐dose endotoxin rat model. <jats:italic>Methods:</jats:italic> Forty male Sprague‐Dawley rats, divided into four feeding groups (structured lipids, structured lipids + endotoxin, physical mixture, physical mixture + endotoxin), received total parenteral nutrition for 48 hours. During the first part of the study, 24 animals were given an injection of live <jats:italic>Escherichia</jats:italic> coli labeled with radioactive iron (<jats:sup>59</jats:sup>Fe) to investigate the function of the reticuloendothelial system. During the second part of the study, the liver and lungs of 16 animals were histologically examined using light and electron microscopy. <jats:italic>Results:</jats:italic> Despite the similar values in the control groups, the animals receiving structured lipids + endotoxin sequestered a significantly greater percentage of bacteria in the liver and spleen (<jats:italic>p</jats:italic> ≤.01) and a significantly lesser percentage in the lung (<jats:italic>p</jats:italic> ≤.05) compared with the animals given physical mixture + endotoxin as part of their diet. Moreover, rats in the physical mixture + endotoxin group showed a microscopically evaluated higher fatty infiltration in the liver than did the structured lipids + endotoxin group. <jats:italic>Conclusions</jats:italic>: The results of this study indicate that chemically defined structured lipids reduce fatty infiltration of the liver compared with a physical mixture of the same compounds in an animal model of metabolic stress. They were accompanied by a better function of the reticuloendothelial system and a lesser bacterial sequestration in the lungs. (Journal of Parenteral and Enteral Nutrition <jats:bold>19</jats:bold>:33–40, 1995)</jats:p>