Beschreibung:
<jats:sec><jats:title>Objective</jats:title><jats:p>Various genome‐wide association studies (GWASs) identified new head and neck cancer (HNC) susceptibility loci, although the evidence has not been systematically summarized. We performed a systematic review and meta‐analyses of the GWASs to identify the most commonly reported genetic loci associated with a risk of HNC.</jats:p></jats:sec><jats:sec><jats:title>Data Sources</jats:title><jats:p>We searched the PubMed, ISI Web of Science, SCOPUS, and GWAS databases to retrieve eligible studies, in English or Italian, published until June 1, 2017.</jats:p></jats:sec><jats:sec><jats:title>Review Methods</jats:title><jats:p>Only GWASs reporting data on the association between single‐nucleotide polymorphisms (SNPs) and HNC were included. The quality of included studies was evaluated using the Q‐Genie tool. Random‐effect meta‐analyses were performed considering only SNPs with at least 1 significant result from the included articles, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Seven studies of case‐control design were included in the review. Five studies on nasopharyngeal cancer (NPC) in Chinese, reporting on 27 different SNPs, were included in meta‐analyses. Results show that 6 SNPs (<jats:italic>rs2076483, rs2975042, rs9258122, rs29232</jats:italic>, and <jats:italic>rs9510787</jats:italic>) had an increased pooled estimates for A risk alleles (OR [95% CI]: 1.55 [1.36‐1.77], 1.90 [1.69‐2.14], 1.47 [1.31‐1.65], 1.52 [1.32‐1.76], and 1.22 [1.13‐1.31], respectively) while G risk allele of <jats:italic>rs3129055</jats:italic> reported an OR of 1.49 (95% CI, 1.33‐1.67).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our systematic review identified 5 SNPs located on chromosome 6 (<jats:italic>rs2076483, rs2975042, rs3129055, rs9258122</jats:italic>, and <jats:italic>rs29232</jats:italic>) and 1 (<jats:italic>rs9510787</jats:italic>) on chromosome 13 as significantly associated with an increased risk of NPC in Chinese.</jats:p></jats:sec>