Beschreibung:
<jats:p> Phospholipase C (PLC) is one signalling effector enzyme whose activity is directly modulated by opioids. Several physiological studies have implicated PLC-linked pathways in in-vivo pain regulation and opioid tolerance. Co-administration of PLC-β<jats:sub> 2/3</jats:sub> activity blocker M119 with morphine resulted in a dramatic increase in morphine-induced amnesic effect in mice, proving a role for β subunit of PLC enzyme in these processes. Administration of morphine to mice at amnesic dose increased PLC-β<jats:sub>3</jats:sub> activity, with respect to basal value, in the membrane-soluble material from anterior cortex and hippocampal formation in brain areas. PLC-β<jats:sub>3</jats:sub> appears to be simultaneously implicated in both analgesic and amnesic effects induced by administration of morphine to mice suggesting a commonality in the molecular mechanisms of morphine-induced analgesia and memory impairment. </jats:p>