> Detailanzeige

Song, Mengmeng; Beyer, Leonie; Kaiser, Lena; Barthel, Henryk; van Eimeren, Thilo; Marek, Ken; Nitschmann, Alexander; Scheifele, Maximilian; Palleis, Carla; Respondek, Gesine; Kern, Maike; Biechele, Gloria; Hammes, Jochen; Bischof, Gèrard; Barbe, Michael; Onur, Özgür; Jessen, Frank; Saur, Dorothee; Schroeter, Matthias L; Rumpf, Jost-Julian; Rullmann, Michael; Schildan, Andreas; Patt, Marianne; Neumaier, Bernd; [...]

Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
  • Beteiligte: Song, Mengmeng; Beyer, Leonie; Kaiser, Lena; Barthel, Henryk; van Eimeren, Thilo; Marek, Ken; Nitschmann, Alexander; Scheifele, Maximilian; Palleis, Carla; Respondek, Gesine; Kern, Maike; Biechele, Gloria; Hammes, Jochen; Bischof, Gèrard; Barbe, Michael; Onur, Özgür; Jessen, Frank; Saur, Dorothee; Schroeter, Matthias L; Rumpf, Jost-Julian; Rullmann, Michael; Schildan, Andreas; Patt, Marianne; Neumaier, Bernd; [...]
  • Erschienen: SAGE Publications, 2021
  • Erschienen in: Journal of Cerebral Blood Flow & Metabolism
  • Sprache: Englisch
  • DOI: 10.1177/0271678x211018904
  • ISSN: 0271-678X; 1559-7016
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> The novel tau-PET tracer [<jats:sup>18</jats:sup>F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [<jats:sup>18</jats:sup>F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [<jats:sup>18</jats:sup>F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [<jats:sup>18</jats:sup>F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 &amp; k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR<jats:sub>30-60</jats:sub>) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1<jats:sub>SRTM</jats:sub>: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2<jats:sub>SRTM</jats:sub>: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p &lt; 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p &lt; 0.0001), lower SUVR<jats:sub>30-60</jats:sub> (1.3 ± 0.2 vs. 1.8 ± 0.3, p &lt; 0.0001) and flatter slopes of the post-perfusion phase (slope<jats:sub>9-60</jats:sub>: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p &lt; 0.0001) when compared to 3/4R-tau cases. [<jats:sup>18</jats:sup>F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies. </jats:p>
  • Zugangsstatus: Freier Zugang