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Medientyp:
E-Artikel
Titel:
Polyneuropathy in Young Siberian Huskies Caused by Degenerative and Inflammatory Diseases
Beteiligte:
Jahns, Hanne;
Vernau, Karen M.;
Nolan, Catherine M.;
O’Neill, Emma J.;
Shiel, Robert E.;
Shelton, G. Diane
Erschienen:
SAGE Publications, 2020
Erschienen in:Veterinary Pathology
Sprache:
Englisch
DOI:
10.1177/0300985820934112
ISSN:
0300-9858;
1544-2217
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> Polyneuropathy is defined as the simultaneous dysfunction of several peripheral nerves. In dogs, a number of breeds are predisposed to a variety of immune-mediated and/or degenerative inherited forms of polyneuropathy, with laryngeal paralysis and/or megaesophagus as important clinical features of many of these conditions. This case series describes degenerative and inflammatory polyneuropathies in 7 young Siberian huskies that were categorized based on clinicopathological characteristics as follows: (1) slowly progressive laryngeal paralysis and megaesophagus caused by primary axonal degeneration with large fiber loss (n = 2); (2) slowly progressive polyneuropathy without megaesophagus or laryngeal paralysis caused by primary axonal degeneration with large fiber loss (n = 2); (3) acute inflammatory demyelinating neuropathy causing sensory, motor and autonomic nerve deficits (n = 2); and (4) ganglioradiculitis (sensory neuronopathy; n = 1). Based on the predominantly young age at onset, slow progression, relatedness of affected dogs, and clinical and pathological similarities with inherited neuropathies reported in other dog breeds, a hereditary basis for the degenerative polyneuropathies in Siberian huskies is suspected. However, 5 different mutations in 3 genes known to cause polyneuropathy in other dog breeds ( NDRG1, ARHGEF10, or RAB3GAP1) were not detected in the affected Siberian huskies suggesting that more genetic variants remain to be identified. This study highlights the varied underlying lesions of polyneuropathies in young Siberian huskies. </jats:p>