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Medientyp:
E-Artikel
Titel:
Review : Biodegradable Microcapsular Drug Delivery Systems: Manufacturing Methodology, Release Control and Targeting Prospects
Beteiligte:
Arshady, Reza
Erschienen:
SAGE Publications, 1990
Erschienen in:Journal of Bioactive and Compatible Polymers
Sprache:
Englisch
DOI:
10.1177/088391159000500308
ISSN:
0883-9115;
1530-8030
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> An overview of the subject of biodegradable microcapsular drug delivery systems is presented from a polymer chemist's viewpoint. Various polymerization and microencapsulation techniques (including emulsion polymerization, interfacial polycondensation, suspension crosslinking, coacer vation/phase separation and solvent evaporation/extraction) suitable for the preparation of biodegradable microcapsules based on proteins, polysaccharides, polyesters, polyamides, or cyanoacrylates are described. Drug release from biodegradable microcapsules is discussed, and examples are presented to illus trate how the rate of drug release can be controlled by adjusting parameters such as microcapsule size, porosity, and crosslinking. Prospects of site-specific chemotherapy by means of passive and active targeting of microcapsular drug carriers are also analyzed. </jats:p>