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Leurs, CE; Twaalfhoven, HAM; Lissenberg-Witte, BI; van Pesch, V; Dujmovic, I; Drulovic, J; Castellazzi, M; Bellini, T; Pugliatti, M; Kuhle, J; Villar, LM; Alvarez-Cermeño, JC; Alvarez-Lafuente, R; Hegen, H; Deisenhammer, F; Walchhofer, LM; Thouvenot, E; Comabella, M; Montalban, X; Vécsei, L; Rajda, C; Galimberti, D; Scarpini, E; Altintas, A; [...]

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

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  • Medientyp: E-Artikel
  • Titel: Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study
  • Beteiligte: Leurs, CE; Twaalfhoven, HAM; Lissenberg-Witte, BI; van Pesch, V; Dujmovic, I; Drulovic, J; Castellazzi, M; Bellini, T; Pugliatti, M; Kuhle, J; Villar, LM; Alvarez-Cermeño, JC; Alvarez-Lafuente, R; Hegen, H; Deisenhammer, F; Walchhofer, LM; Thouvenot, E; Comabella, M; Montalban, X; Vécsei, L; Rajda, C; Galimberti, D; Scarpini, E; Altintas, A; [...]
  • Erschienen: SAGE Publications, 2020
  • Erschienen in: Multiple Sclerosis Journal
  • Sprache: Englisch
  • DOI: 10.1177/1352458519845844
  • ISSN: 1352-4585; 1477-0970
  • Schlagwörter: Neurology (clinical) ; Neurology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective:</jats:title><jats:p> To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2–138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5–22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85–0.90) was higher than OCB (0.82; 95%CI = 0.79–0.85; p &lt; 0.001), but specificity (0.83; 95% CI = 0.78–0.88) was lower (OCB = 0.92; 95% CI = 0.89–0.96; p &lt; 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. </jats:p></jats:sec>