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Comi, G; Battaglia, MA; Bertolotto, A; Sette, M Del; Ghezzi, A; Malferrari, G; Salvetti, M; Sormani, MP; Tesio, L; Stolz, E; Zaratin, P; Mancardi, G; Baracchini, Claudio; Bergamaschi, Roberto; Bertolotto, Antonio; Bortolon, Franca; Bratina, Alessio; Morra, Vincenzo Brescia; Buccafusca, Maria; Busso, Marco; Capra, Ruggero; Carraro, Nicola; Cavalla, Paola; Cecconi, Pietro; [...]

Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study

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  • Medientyp: E-Artikel
  • Titel: Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study
  • Beteiligte: Comi, G; Battaglia, MA; Bertolotto, A; Sette, M Del; Ghezzi, A; Malferrari, G; Salvetti, M; Sormani, MP; Tesio, L; Stolz, E; Zaratin, P; Mancardi, G; Baracchini, Claudio; Bergamaschi, Roberto; Bertolotto, Antonio; Bortolon, Franca; Bratina, Alessio; Morra, Vincenzo Brescia; Buccafusca, Maria; Busso, Marco; Capra, Ruggero; Carraro, Nicola; Cavalla, Paola; Cecconi, Pietro; [...]
  • Erschienen: SAGE Publications, 2013
  • Erschienen in: Multiple Sclerosis Journal
  • Sprache: Englisch
  • DOI: 10.1177/1352458513501231
  • ISSN: 1352-4585; 1477-0970
  • Schlagwörter: Neurology (clinical) ; Neurology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Background:</jats:title><jats:p> Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). </jats:p></jats:sec><jats:sec><jats:title>Objectives:</jats:title><jats:p> The CoSMo study evaluated the association between CCSVI and MS. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> The study involved 35 MS centers across Italy and included 1874 subjects aged 18–55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72–3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53–4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47–2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> CCSVI is not associated with MS. </jats:p></jats:sec>