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Gharaibeh, Khaled; Aladamat, Nameer; Samara, Mohammad; Mierzwa, Adam T.; Ali, Ahsan; Zaidi, Syed; Jumaa, Mouhammad

Hyperdense sign as a predictor for successful recanalization and clinical outcome in acute ischemic stroke: A systematic review and meta-analysis

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  • Medientyp: E-Artikel
  • Titel: Hyperdense sign as a predictor for successful recanalization and clinical outcome in acute ischemic stroke: A systematic review and meta-analysis
  • Beteiligte: Gharaibeh, Khaled; Aladamat, Nameer; Samara, Mohammad; Mierzwa, Adam T.; Ali, Ahsan; Zaidi, Syed; Jumaa, Mouhammad
  • Erschienen: SAGE Publications, 2024
  • Erschienen in: Interventional Neuroradiology (2024)
  • Sprache: Englisch
  • DOI: 10.1177/15910199241235431
  • ISSN: 1591-0199; 2385-2011
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p> To assess the prognostic values of hyperdense sign on pretreatment non-contrast head CT scan for successful recanalization (mTICI ≥2b) and 90-day good functional outcome (mRs 0-2) in patients with acute ischemic stroke undergoing mechanical thrombectomy (MT). </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Literature search on PubMed, EMBASE, and Cochrane databases from inception up to 1 November 2023 was conducted. Twelve studies which reported hyperdense sign, recanalization and clinical outcomes were included in qualitative synthesis and meta-analysis. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Pooled analysis demonstrated a statistically significant association between successful recanalization and hyperdense sign-positive patients who underwent MT (odd ratios (OR) = 1.47, 95% confidence interval (CI) = 1.03–2.10, p = 0.04). No statistically significant association was demonstrated between presence of hyperdense sign and good functional outcome (OR = 1.04, 95% CI: 0.72–1.49, p = 0.85) or symptomatic intracranial hemorrhage sICH (OR: 1.80, 95% CI 0.72–4.47, p = 0.21) </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> This meta-analysis demonstrated that pre-intervention hyperdense sign on CT imaging might be useful in prediction of successful recanalization after MT. </jats:p></jats:sec>