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Medientyp:
E-Artikel
Titel:
Hypomagnesemia in persons with type 1 diabetes: associations with clinical parameters and oxidative stress
Beteiligte:
van Dijk, Peter R.;
Waanders, F.;
Qiu, Jiedong;
de Boer, Hannah H. R.;
van Goor, H.;
Bilo, H. J. G.
Erschienen:
SAGE Publications, 2020
Erschienen in:
Therapeutic Advances in Endocrinology and Metabolism, 11 (2020), Seite 204201882098024
Sprache:
Englisch
DOI:
10.1177/2042018820980240
ISSN:
2042-0188;
2042-0196
Entstehung:
Anmerkungen:
Beschreibung:
Background: Among persons with type 1 diabetes mellitus (T1DM) low concentrations of magnesium have been reported. Previous (small) studies also suggested a relation of hypomagnesemia with (poor) glycaemic control and complications. We aimed to investigate the magnitude of hypomagnesemia and the associations between magnesium with parameters of routine T1DM care in a population of unselected outpatients. Methods: As part of a prospective cohort study, initially designed to measure quality of life and oxidative stress, data from 207 patients with a mean age of 45 [standard deviation (SD) 12] years, 58% male, diabetes duration 22 [interquartile range (IQR) 16, 31] years and glycated haemoglobin (HbA1c) of 60 (SD 11) mmol/mol [7.6 (SD 1.0)%] were examined. Hypomagnesemia was defined as a concentration below <0.7 mmol/l. Results: Mean magnesium concentration was 0.78 (SD 0.05) mmol/l. A deficiency was present in 4.3% of participants. Among these persons, mean concentration was 0.66 (SD 0.03) mmol/l. There was no correlation between magnesium and HbA1c at baseline ( r = –0.014, p = 0.843). In multivariable analysis, free thiols (reflecting the degree of oxidative stress) were significantly and negatively associated with magnesium concentrations. Conclusion: In this cohort of T1DM outpatients, the presence of hypomagnesemia was infrequent and, if present, relative mild. Magnesium was not associated with glycaemic control nor with presence of micro- and macrovascular complications. Although these results need confirmation, in particular the negative association of magnesium with free thiols, this suggests that hypomagnesemia is not a relevant topic in routine care for people with T1DM.