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Medientyp:
E-Artikel
Titel:
Experience with gemtuzumab ozogamycin (“mylotarg”) and all-trans retinoic acid in untreated acute promyelocytic leukemia
Beteiligte:
Estey, Elihu H.;
Giles, Francis J.;
Beran, Miloslav;
O'Brien, Susan;
Pierce, Sherry A.;
Faderl, Stefan H.;
Cortes, Jorge E.;
Kantarjian, Hagop M.
Erschienen:
American Society of Hematology, 2002
Erschienen in:
Blood, 99 (2002) 11, Seite 4222-4224
Sprache:
Englisch
DOI:
10.1182/blood-2001-12-0174
ISSN:
1528-0020;
0006-4971
Entstehung:
Anmerkungen:
Beschreibung:
We administered gemtuzumab ozogamycin (“mylotarg”; 9 mg/m2 day 1 or 5) and all-trans retinoic acid (ATRA) to 19 patients with untreated acute promyelocytic leukemia (APL). There were 3 patients who also received idarubicin because of a white blood cell (WBC) count of more than 30 000/μL. In complete remission (CR), patients were to receive 8 courses of mylotarg (9 mg/m2 every 4 to 5 weeks) and ATRA; idarubicin was added only for persistent or recurrent polymerase chain reaction (PCR) positivity. The CR rate was 16/19 (84%). All 12 patients tested to date were PCR-negative 2 to 4 months from CR date; none of the 7 patients evaluated subsequently have reverted to PCR positivity (median follow-up in CR was 5 months, up to 14 months). Mylotarg was well tolerated. A median of 5 post-CR courses have been given to date with 3 patients having currently received 8 post-CR courses, and 4 patients receiving 7 post-CR courses. Mylotarg appears active in APL, and repeated administration is feasible.