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Medientyp:
E-Artikel
Titel:
Platelet activation induced by human antibodies to interleukin-8
Beteiligte:
Regnault, Véronique;
de Maistre, Emmanuel;
Carteaux, Jean-Pierre;
Gruel, Yves;
Nguyen, Philippe;
Tardy, Brigitte;
Lecompte, Thomas
Erschienen:
American Society of Hematology, 2003
Erschienen in:
Blood, 101 (2003) 4, Seite 1419-1421
Sprache:
Englisch
DOI:
10.1182/blood-2002-02-0620
ISSN:
1528-0020;
0006-4971
Entstehung:
Anmerkungen:
Beschreibung:
Some cases of heparin-induced thrombocytopenia (HIT) have been reported to be associated with antibodies against interleukin-8 (IL-8), a chemokine related to platelet factor 4. We found that sera from 5 HIT patients containing immunoglobulin G (IgG) or IgM antibodies to IL-8, as evidenced using surface plasmon resonance spectroscopy, were able to trigger IL-8–dependent activation of washed platelets, leading to procoagulant activity. This activation occurred at IL-8 concentrations achievable in vivo and was facilitated by heparin (0.1 U/mL). Activation was also induced by affinity-purified anti–IL-8 IgG and involved FcγRIIa. In the 2 patients who could be followed up, antibodies were no longer detectable 4 months after heparin withdrawal. One additional patient with paraneoplastic recurrent thrombosis without thrombocytopenia was found to have platelet-activating anti–IL-8 IgM, but in this case heparin was inhibitory. This is another example of potentially pathogenic platelet activation by antibodies.