• Medientyp: E-Artikel
  • Titel: Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition
  • Beteiligte: Nazir, Sumra; Gadi, Ihsan; Al-Dabet, Moh’d Mohanad; Elwakiel, Ahmed; Kohli, Shrey; Ghosh, Sanchita; Manoharan, Jayakumar; Ranjan, Satish; Bock, Fabian; Braun-Dullaeus, Ruediger C.; Esmon, Charles T.; Huber, Tobias B.; Camerer, Eric; Dockendorff, Chris; Griffin, John H.; Isermann, Berend; Shahzad, Khurrum
  • Erschienen: American Society of Hematology, 2017
  • Erschienen in: Blood
  • Sprache: Englisch
  • DOI: 10.1182/blood-2017-05-782102
  • ISSN: 0006-4971; 1528-0020
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  • Beschreibung: <jats:title>Key Points</jats:title> <jats:p>aPC protects from myocardial and renal IRIs by restricting mTORC1-mediated activation of the Nlrp3 inflammasome. Nlrp3 inflammasome suppression by aPC is independent of its anticoagulant effect, depends on PAR-1, and can be mimicked by parmodulin-2.</jats:p>
  • Zugangsstatus: Freier Zugang