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Medientyp:
E-Artikel
Titel:
CTLA-4: a moving target in immunotherapy
Beteiligte:
Rowshanravan, Behzad;
Halliday, Neil;
Sansom, David M.
Erschienen:
American Society of Hematology, 2018
Erschienen in:Blood
Sprache:
Englisch
DOI:
10.1182/blood-2017-06-741033
ISSN:
0006-4971;
1528-0020
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are responsible for various aspects of T-cell immune regulation. The family includes CD28, CTLA-4, and ICOS as well as other proteins, including PD-1, BTLA, and TIGIT. These receptors have both stimulatory (CD28, ICOS) and inhibitory roles (CTLA-4, PD-1, BTLA, and TIGIT) in T-cell function. Increasingly, these pathways are targeted as part of immune modulatory strategies to treat cancers, referred to generically as immune checkpoint blockade, and conversely to treat autoimmunity and CTLA-4 deficiency. Here, we focus on the biology of the CD28/CTLA-4 pathway as a framework for understanding the impacts of therapeutic manipulation of this pathway.</jats:p>