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Medientyp:
E-Artikel
Titel:
Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes
Beteiligte:
Taveirne, Sylvie;
Filtjens, Jessica;
Van Ammel, Els;
De Colvenaer, Veerle;
Kerre, Tessa;
Taghon, Tom;
Vandekerckhove, Bart;
Plum, Jean;
Held, Werner;
Leclercq, Georges
Erschienen:
American Society of Hematology, 2011
Erschienen in:
Blood, 118 (2011) 2, Seite 339-347
Sprache:
Englisch
DOI:
10.1182/blood-2011-01-331124
ISSN:
0006-4971;
1528-0020
Entstehung:
Anmerkungen:
Beschreibung:
AbstractThe engagement of inhibitory receptors specific for major histocompatibility complex class I (MHC-I) molecules educates natural killer (NK) cells, meaning the improvement of the response of activation receptors to subsequent stimulation. It is not known whether inhibitory MHC-I receptors educate only NK cells or whether they improve the responsiveness of all cell types, which express them. To address this issue, we analyzed the expression of inhibitory MHC-I receptors on intestinal intraepithelial lymphocytes (iIELs) and show that T-cell receptor (TCR)-αβ CD8αα iIELs express multiple inhibitory receptors specific for MHC-I molecules, including CD94/NKG2A, Ly49A, and Ly49G2. However, the presence of MHC-I ligand for these receptors did not improve the response of iIELs to activation via the TCR. The absence of iIEL education by MHC-I receptors was not related to a lack of inhibitory function of these receptors in iIELs and a failure of these receptors to couple to the TCR. Thus, unlike NK cells, iIELs do not undergo an MHC-I–guided education process. These data suggest that education is an NK cell–specific function of inhibitory MHC-I receptors.