• Medientyp: E-Artikel
  • Titel: Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)
  • Beteiligte: Zhang, Lin; Urtz, Nicole; Gaertner, Florian; Legate, Kyle R.; Petzold, Tobias; Lorenz, Michael; Mazharian, Alexandra; Watson, Steve P.; Massberg, Steffen
  • Erschienen: American Society of Hematology, 2013
  • Erschienen in: Blood
  • Sprache: Englisch
  • DOI: 10.1182/blood-2012-12-473884
  • ISSN: 0006-4971; 1528-0020
  • Schlagwörter: Cell Biology ; Hematology ; Immunology ; Biochemistry
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  • Beschreibung: <jats:title>Key Points</jats:title> <jats:p>Sphk2 provides a source of intracellular S1P that tightly controls thrombopoiesis by regulating SFK expression and activity in MKs. Modulation of intracellular S1P by regulating Sphk2 may provide a new strategy to enhance platelet production in patients with thrombocytopenia.</jats:p>
  • Zugangsstatus: Freier Zugang