Hole, Paul S.;
Zabkiewicz, Joanna;
Munje, Chinmay;
Newton, Zarabeth;
Pearn, Lorna;
White, Paul;
Marquez, Nuria;
Hills, Robert K.;
Burnett, Alan K.;
Tonks, Alex;
Darley, Richard L.
Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
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Medientyp:
E-Artikel
Titel:
Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
Beteiligte:
Hole, Paul S.;
Zabkiewicz, Joanna;
Munje, Chinmay;
Newton, Zarabeth;
Pearn, Lorna;
White, Paul;
Marquez, Nuria;
Hills, Robert K.;
Burnett, Alan K.;
Tonks, Alex;
Darley, Richard L.
Erschienen:
American Society of Hematology, 2013
Erschienen in:
Blood, 122 (2013) 19, Seite 3322-3330
Sprache:
Englisch
DOI:
10.1182/blood-2013-04-491944
ISSN:
0006-4971;
1528-0020
Entstehung:
Anmerkungen:
Beschreibung:
Key Points More than 60% of primary AML blasts constitutively produce high levels of NOX-derived reactive oxygen species (ROS), which drives AML proliferation. High ROS AMLs show depleted antioxidant defenses but evade the oxidative stress response through suppression of p38MAPK signaling.