RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling

Medientyp: E-Artikel
Titel: RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Beteiligte: Kapralova, Katarina; Lanikova, Lucie; Lorenzo, Felipe; Song, Jihyun; Horvathova, Monika; Divoky, Vladimir; Prchal, Josef T.
Erschienen: American Society of Hematology, 2014
Erschienen in: Blood
Sprache: Englisch
DOI: 10.1182/blood-2013-10-534222
ISSN: 0006-4971; 1528-0020
Schlagwörter: Cell Biology ; Hematology ; Immunology ; Biochemistry
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Beschreibung: <jats:title>Key Points</jats:title> <jats:p>Overexpression of RUNX1 and its target NF-E2 is not specific for PV but is also seen in polycythemias due to augmented hypoxia sensing. Elevated levels of RUNX1 and NF-E2 are not specific for primary polycythemias, as these are not present in PFCP.</jats:p>
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