• Medientyp: E-Artikel
  • Titel: CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs
  • Beteiligte: Jitschin, Regina; Braun, Martina; Büttner, Maike; Dettmer-Wilde, Katja; Bricks, Juliane; Berger, Jana; Eckart, Michael J.; Krause, Stefan W.; Oefner, Peter J.; Le Blanc, Katarina; Mackensen, Andreas; Mougiakakos, Dimitrios
  • Erschienen: American Society of Hematology, 2014
  • Erschienen in: Blood
  • Sprache: Englisch
  • DOI: 10.1182/blood-2013-12-546416
  • ISSN: 0006-4971; 1528-0020
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  • Beschreibung: <jats:title>Key Points</jats:title> <jats:p>Monocytic IDOhi MDSCs are increased in CLL patients, suppress T cells, and promote TReg induction. CLL cells induce conversion of monocytes into MDSCs suggesting bidirectional crosstalk between CLL cells, MDSCs, and TRegs.</jats:p>
  • Zugangsstatus: Freier Zugang