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Herold, Michael; Haas, Antje; Srock, Stephanie; Neser, Sabine; Al Ali, Kathrin H.; Neubauer, Andreas; Doelken, Gottfried; Naumann, Ralph; Fietz, Thomas; Freund, Mathias; Rohrberg, Robert; Hoeffken, Klaus; Mohren, Martin; Ittel, Thomas H.; Kettner, Erika

Immunochemotherapy (R-MCP) Is Not Superior to Chemotherapy (MCP) Alone in Advanced Mantle Cell Lymphoma - 42 Months Follow Up Results of the OSHO 39 Study

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  • Medientyp: E-Artikel
  • Titel: Immunochemotherapy (R-MCP) Is Not Superior to Chemotherapy (MCP) Alone in Advanced Mantle Cell Lymphoma - 42 Months Follow Up Results of the OSHO 39 Study
  • Beteiligte: Herold, Michael; Haas, Antje; Srock, Stephanie; Neser, Sabine; Al Ali, Kathrin H.; Neubauer, Andreas; Doelken, Gottfried; Naumann, Ralph; Fietz, Thomas; Freund, Mathias; Rohrberg, Robert; Hoeffken, Klaus; Mohren, Martin; Ittel, Thomas H.; Kettner, Erika
  • Erschienen: American Society of Hematology, 2007
  • Erschienen in: Blood, 110 (2007) 11, Seite 4474-4474
  • Sprache: Englisch
  • DOI: 10.1182/blood.v110.11.4474.4474
  • ISSN: 1528-0020; 0006-4971
  • Schlagwörter: Cell Biology ; Hematology ; Immunology ; Biochemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract Introduction: Rituximab plus chemotherapy has been proved to be the standard in treating advanced follicular lymphoma. However in mantle cell lymphoma (MCL) the results are still controversial. Methods: In a prospective randomised trial (OSHO#39) we compared the efficacy and toxicity of MCP chemotherapy(mitoxantrone 8 mg/m2 d 1+2, chlormabucil 3x3 mg/m2 d 1–5 and prednisolone 25 mg/m2 d q 4 weeks)versus MCP plus rituximab (375 mg/m2 d -1) in advanced indolent lymphoma and mantle cell lymphoma. Here we present the results of the MCL subgroup (n=90) among the 358 randomised patients (FL, MCL, LPL). Study endpoints included overall and complete response rate (RR + CR), progression free survival (PFS), event free survival (EFS), overall survival (OS) and toxicities. Results: with a median follow-up of 43 months for the MCL subgroup we can provide relatively mature data. Concerning toxicities there was no striking difference between the treatment groups. The treatment results for the MCL patients are as follows: Conclusions: Concerning all end-points R-MCP is not superior to MCP chemotherapy alone in advanced mantle cell lymphoma. Immunochemotherapy is obviously not the solution for this poor prognosis lymphoma entity. Results R-MCP n=44 MCP n=46 p-value Response Rate 70,5% 63% .5074 Complete Responses 31,8% 15,2% .0822 PFS median 20,5 months 19 months .2482 PFS 42 months 31% 14% EFS median 19 months 14 months .1369 EFS 42 months 27% 11,5% OS median 56 months 50 months .4862 OS 42 months 60% 61%
  • Zugangsstatus: Freier Zugang