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Takei, Yusuke; Yamada, Mitsuhiro; Saito, Koji; Kameyama, Yoshinobu; Sugiura, Hisatoshi; Makiguchi, Tomonori; Fujino, Naoya; Koarai, Akira; Toyama, Hiroaki; Saito, Kazutomo; Ejima, Yutaka; Kawazoe, Yu; Kudo, Daisuke; Kushimoto, Shigeki; Yamauchi, Masanori; Ichinose, Masakazu

Increase in circulating ACE-positive endothelial microparticles during acute lung injury

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  • Medientyp: E-Artikel
  • Titel: Increase in circulating ACE-positive endothelial microparticles during acute lung injury
  • Beteiligte: Takei, Yusuke; Yamada, Mitsuhiro; Saito, Koji; Kameyama, Yoshinobu; Sugiura, Hisatoshi; Makiguchi, Tomonori; Fujino, Naoya; Koarai, Akira; Toyama, Hiroaki; Saito, Kazutomo; Ejima, Yutaka; Kawazoe, Yu; Kudo, Daisuke; Kushimoto, Shigeki; Yamauchi, Masanori; Ichinose, Masakazu
  • Erschienen: European Respiratory Society (ERS), 2019
  • Erschienen in: European Respiratory Journal
  • Sprache: Englisch
  • DOI: 10.1183/13993003.01188-2018
  • ISSN: 1399-3003; 0903-1936
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Circulating endothelial microparticles (EMPs) are considered to be markers of endothelial injury, and lung microvascular endothelial cells express higher levels of angiotensin-converting enzyme (ACE). The aim of this study is to examine whether the number of ACE<jats:sup>+</jats:sup>microvascular EMPs could be a prognostic marker for the development of acute respiratory distress syndrome (ARDS) in septic patients.</jats:p><jats:p>The numbers of EMPs and ACE<jats:sup>+</jats:sup>EMPs in the culture supernatant from human microvascular endothelial cells, as well as in the blood of mouse lung injury models and septic patients (n=82), were examined using flow cytometry.</jats:p><jats:p>ACE<jats:sup>+</jats:sup>EMPs in the culture supernatant from pulmonary microvascular endothelial cells increased after exposure to an inflammatory stimulus. In the mouse lung injury models, the circulating ACE<jats:sup>+</jats:sup>EMPs and ACE<jats:sup>+</jats:sup>EMP/EMP ratio were higher than in the controls (p&lt;0.001). The ACE<jats:sup>+</jats:sup>EMP/EMP ratio was correlated with the wet/dry lung ratio (r<jats:sub>s</jats:sub>=0.775, p&lt;0.001). The circulating ACE<jats:sup>+</jats:sup>EMPs and ACE<jats:sup>+</jats:sup>EMP/EMP ratio on admission were significantly increased in septic patients who developed ARDS compared with septic patients who did not (p&lt;0.001).</jats:p><jats:p>Therefore, circulating ACE<jats:sup>+</jats:sup>EMPs may be a prognostic marker for the development of ARDS in the septic patients.</jats:p>
  • Zugangsstatus: Freier Zugang