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Wetzke, Martin; Schütz, Katharina; Kopp, Matthias Volkmar; Seidenberg, Jürgen; Vogelberg, Christian; Ankermann, Tobias; Happle, Christine; Voigt, Gesche; Köster, Holger; Illig, Thomas; Lex, Christiane; Schuster, Antje; Maier, Ralph; Panning, Marcus; Barten, Grit; Rohde, Gernot; Welte, Tobias; Hansen, Gesine

Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia

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  • Medientyp: E-Artikel
  • Titel: Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia
  • Beteiligte: Wetzke, Martin; Schütz, Katharina; Kopp, Matthias Volkmar; Seidenberg, Jürgen; Vogelberg, Christian; Ankermann, Tobias; Happle, Christine; Voigt, Gesche; Köster, Holger; Illig, Thomas; Lex, Christiane; Schuster, Antje; Maier, Ralph; Panning, Marcus; Barten, Grit; Rohde, Gernot; Welte, Tobias; Hansen, Gesine
  • Erschienen: European Respiratory Society (ERS), 2023
  • Erschienen in: ERJ Open Research, 9 (2023) 2, Seite 00286-2022
  • Sprache: Englisch
  • DOI: 10.1183/23120541.00286-2022
  • ISSN: 2312-0541
  • Schlagwörter: Pulmonary and Respiratory Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: BackgroundPaediatric community-acquired pneumonia (CAP) is a leading cause of paediatric morbidity. However, particularly for outpatients with paediatric CAP, data on aetiology and management are scarce.MethodsThe prospective pedCAPNETZ study multicentrically enrols children and adolescents with outpatient-treated or hospitalised paediatric CAP in Germany. Blood and respiratory specimens were collected systematically, and comprehensive analyses of pathogen spectra were conducted. Follow-up evaluations were performed until day 90 after enrolment.ResultsBetween December 2014 and August 2020, we enrolled 486 children with paediatric CAP at eight study sites, 437 (89.9%) of whom had radiographic evidence of paediatric CAP. Median (interquartile range) age was 4.5 (1.6–6.6) years, and 345 (78.9%) children were hospitalised. The most prevalent symptoms at enrolment were cough (91.8%), fever (89.2%) and tachypnoea (62.0%). Outpatients were significantly older, displayed significantly lower C-reactive protein levels and were significantly more likely to be symptom-free at follow-up days 14 and 90. Pathogens were detected in 90.3% of all patients (one or more viral pathogens in 68.1%; one or more bacterial strains in 18.7%; combined bacterial/viral pathogens in 4.1%). Parainfluenza virus andMycoplasma pneumoniaewere significantly more frequent in outpatients. The proportion of patients with antibiotic therapy was comparably high in both groups (92.4% of outpatientsversus86.2% of hospitalised patients).ConclusionWe present first data on paediatric CAP with comprehensive analyses in outpatients and hospitalised cases and demonstrate high detection rates of viral pathogens in both groups. Particularly in young paediatric CAP patients with outpatient care, antibiotic therapy needs to be critically debated.
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