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Gordillo-Moscoso, Antonio; Ruiz, Emilio; Carnero, Manuel; Reguillo, Fernando; Rodriguez, Enrique; Tejerina, Teresa; Redondo, Santiago

Relationship between serum levels of triglycerides and vascular inflammation, measured as COX-2, in arteries from diabetic patients: a translational study

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  • Medientyp: E-Artikel
  • Titel: Relationship between serum levels of triglycerides and vascular inflammation, measured as COX-2, in arteries from diabetic patients: a translational study
  • Beteiligte: Gordillo-Moscoso, Antonio; Ruiz, Emilio; Carnero, Manuel; Reguillo, Fernando; Rodriguez, Enrique; Tejerina, Teresa; Redondo, Santiago
  • Erschienen: Springer Science and Business Media LLC, 2013
  • Erschienen in: Lipids in Health and Disease, 12 (2013) 1
  • Sprache: Englisch
  • DOI: 10.1186/1476-511x-12-62
  • ISSN: 1476-511X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Inflammation is a common feature in the majority of cardiovascular disease, including Diabetes Mellitus (DM). Levels of pro-inflammatory markers have been found in increasing levels in serum from diabetic patients (DP). Moreover, levels of Cyclooxygenase-2 (COX-2) are increased in coronary arteries from DP.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Through a cross-sectional design, patients who underwent CABG were recruited. Vascular smooth muscle cells (VSMC) were cultured and COX-2 was measured by western blot. Biochemical and clinical data were collected from the medical record and by blood testing. COX-2 expression was analyzed in internal mammary artery cross-sections by confocal microscopy. Eventually, PGI<jats:sub>2</jats:sub> and PGE<jats:sub>2</jats:sub> were assessed from VSMC conditioned media by ELISA.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Only a high glucose concentration, but a physiological concentration of triglycerides exposure of cultured human VSMC derived from non-diabetic patients increased COX-2 expression. Diabetic patients showed increasing serum levels of glucose, Hb1<jats:sub>ac</jats:sub> and triglycerides. The bivariate analysis of the variables showed that triglycerides was positively correlated with the expression of COX-2 in internal mammary arteries from patients (r<jats:sup>2</jats:sup> = 0.214, P &lt; 0.04).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>We conclude that is not the glucose blood levels but the triglicerydes leves what increases the expression of COX-2 in arteries from DP.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang