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Tun, May T; Pai, Reetesh K; Kwok, Shirley; Dong, Aiwen; Gupta, Aparna; Visser, Brendan C; Norton, Jeff A; Poultsides, George A; Banerjee, Subhas; Van Dam, Jacques; Chen, Ann M; Friedland, Shai; Scott, Brennan A; Verma, Rahul; Lowe, Anson W; Park, Walter G

Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts

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  • Medientyp: E-Artikel
  • Titel: Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts
  • Beteiligte: Tun, May T; Pai, Reetesh K; Kwok, Shirley; Dong, Aiwen; Gupta, Aparna; Visser, Brendan C; Norton, Jeff A; Poultsides, George A; Banerjee, Subhas; Van Dam, Jacques; Chen, Ann M; Friedland, Shai; Scott, Brennan A; Verma, Rahul; Lowe, Anson W; Park, Walter G
  • Erschienen: Springer Science and Business Media LLC, 2012
  • Erschienen in: BMC Gastroenterology
  • Sprache: Englisch
  • DOI: 10.1186/1471-230x-12-15
  • ISSN: 1471-230X
  • Schlagwörter: Gastroenterology ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Accurate tests to diagnose adenocarcinoma and high-grade dysplasia among mucinous pancreatic cysts are clinically needed. This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker to differentiate non-mucinous, benign mucinous, and malignant mucinous cysts.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>A single-center retrospective study to evaluate AREG levels in pancreatic cyst fluid by ELISA from 33 patients with a histological gold standard was performed.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Among the cyst fluid samples, the median (IQR) AREG levels for non-mucinous (n = 6), benign mucinous (n = 15), and cancerous cysts (n = 15) were 85 pg/ml (47-168), 63 pg/ml (30-847), and 986 pg/ml (417-3160), respectively. A significant difference between benign mucinous and malignant mucinous cysts was observed (<jats:italic>p</jats:italic> = 0.025). AREG levels greater than 300 pg/ml possessed a diagnostic accuracy for cancer or high-grade dysplasia of 78% (sensitivity 83%, specificity 73%).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Cyst fluid AREG levels are significantly higher in cancerous and high-grade dysplastic cysts compared to benign mucinous cysts. Thus AREG exhibits potential clinical utility in the evaluation of pancreatic cysts.</jats:p> </jats:sec>
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