Beschreibung:
<jats:title>Abstract</jats:title>
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<jats:title>Background</jats:title>
<jats:p>Aim of this <jats:italic>in-vitro</jats:italic>-study was to assess the remineralization potential of a tooth cleaning tablet with different fluoride content.</jats:p>
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<jats:title>Methods</jats:title>
<jats:p>Twenty three caries free impacted third molars were examined, enamel surfaces were wax coated leaving two 3 × 4 mm windows for exposure to demineralization/remineralization cycles. The teeth were randomly assigned to 4 groups of 5 control and 6 experimental teeth. Demineralization by standardised HEC-gel, pH 4.7 at 37°C for 72 h, was alternated by rinsing in remineralization solution, pH 7.0 at 37°C for 72 h, total challenge time 432 h. The negative control group N was treated during remineralization cycles with saline; positive control group P was treated with remineralization solution; experimental group D1 was exposed to remineralization solution containing Denttabs<jats:sup>®</jats:sup>-tablets with 1450 ppm F; experimental group D2 was exposed to remineralization solution and Denttabs<jats:sup>®</jats:sup>-tablets with 4350 ppm F. Each tooth was cut into serial sections and analyzed by polarized light microscopy for assessment of the different zones of white-spot lesions in 3 representative sections. Statistical analysis was based on the <jats:italic>Mann-Whitney</jats:italic>-Test.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>Both control groups N(-) and P(+) exhibited characteristic white-spot lesions. The remineralization and the demineralization inhibition of the lesions increased considerably from N<P < D1<D2. Denttabs<jats:sup>®</jats:sup>-2 administration showed partial/total remineralization including lamination and/or disappearance of the body of the lesion. The different results of all 4 groups were statistically highly significant (p < 0.01) with both tests.</jats:p>
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<jats:title>Conclusion</jats:title>
<jats:p>Based on these results the novel Denttabs<jats:sup>®</jats:sup> formulation represents a highly effective oral hygiene product and the remineralization is correlated to the fluoride content.</jats:p>
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