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He, Qiang; Wang, Wenjing; Xiong, Yang; Tao, Chuanyuan; Ma, Lu; Ma, Junpeng; You, Chao; Anttila, Verneri; Artto, Ville; Belin, Andrea C.; Bjornsdottir, Anna; Bjornsdottir, Gyda; Boomsma, Dorret I.; Børte, Sigrid; Chalmer, Mona A.; Chasman, Daniel I.; Cormand, Bru; Cuenca-Leon, Ester; Davey-Smith, George; de Boer, Irene; Dichgans, Martin; Esko, Tonu; Freilinger, Tobias; Gormley, Padhraig; [...]

A causal effects of gut microbiota in the development of migraine

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  • Medientyp: E-Artikel
  • Titel: A causal effects of gut microbiota in the development of migraine
  • Beteiligte: He, Qiang; Wang, Wenjing; Xiong, Yang; Tao, Chuanyuan; Ma, Lu; Ma, Junpeng; You, Chao; Anttila, Verneri; Artto, Ville; Belin, Andrea C.; Bjornsdottir, Anna; Bjornsdottir, Gyda; Boomsma, Dorret I.; Børte, Sigrid; Chalmer, Mona A.; Chasman, Daniel I.; Cormand, Bru; Cuenca-Leon, Ester; Davey-Smith, George; de Boer, Irene; Dichgans, Martin; Esko, Tonu; Freilinger, Tobias; Gormley, Padhraig; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: The Journal of Headache and Pain
  • Sprache: Englisch
  • DOI: 10.1186/s10194-023-01609-x
  • ISSN: 1129-2377
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The causal association between the gut microbiome and the development of migraine and its subtypes remains unclear.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The single nucleotide polymorphisms concerning gut microbiome were retrieved from the gene-wide association study (GWAS) of the MiBioGen consortium. The summary statistics datasets of migraine, migraine with aura (MA), and migraine without aura (MO) were obtained from the GWAS meta-analysis of the International Headache Genetics Consortium (IHGC) and FinnGen consortium. Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In IHGC datasets, ten, five, and nine bacterial taxa were found to have a causal association with migraine, MA, and MO, respectively, (IVW, all <jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>Genus.Coprococcus3</jats:italic> and <jats:italic>genus.Anaerotruncus</jats:italic> were validated in FinnGen datasets. Nine, twelve, and seven bacterial entities were identified for migraine, MA, and MO, respectively. The causal association still exists in <jats:italic>family.Bifidobacteriaceae</jats:italic> and <jats:italic>order.Bifidobacteriales</jats:italic> for migraine and MO after FDR correction. The heterogeneity and pleiotropy analyses confirmed the robustness of IVW results.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Our study demonstrates that gut microbiomes may exert causal effects on migraine, MA, and MO. We provide novel evidence for the dysfunction of the gut-brain axis on migraine. Future study is required to verify the relationship between gut microbiome and the risk of migraine and its subtypes and illustrate the underlying mechanism between them.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang