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Hernández-Quiles, Rubén; Merino-Lucas, Esperanza; Boix, Vicente; Fernández-Gil, Adela; Rodríguez-Díaz, Juan C.; Gimeno, Adelina; Valero, Beatriz; Sánchez-Martínez, Rosario; Ramos-Rincón, Jose-Manuel

Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection: retrospective cohort study

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  • Medientyp: E-Artikel
  • Titel: Bacteraemia and quick Sepsis Related Organ Failure Assessment (qSOFA) are independent risk factors for long-term mortality in very elderly patients with suspected infection: retrospective cohort study
  • Beteiligte: Hernández-Quiles, Rubén; Merino-Lucas, Esperanza; Boix, Vicente; Fernández-Gil, Adela; Rodríguez-Díaz, Juan C.; Gimeno, Adelina; Valero, Beatriz; Sánchez-Martínez, Rosario; Ramos-Rincón, Jose-Manuel
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: BMC Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1186/s12879-022-07242-4
  • ISSN: 1471-2334
  • Schlagwörter: Infectious Diseases
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>In older adult patients, bloodstream infections cause significant mortality. However, data on long-term prognosis in very elderly patients are scarce. This study aims to assess 1-year mortality from bacteraemia in very elderly patients. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Retrospective cohort study in inpatients aged 80 years or older and suspected of having sepsis. Patients with (n = 336) and without (n = 336) confirmed bacteraemia were matched for age, sex, and date of culture, and their characteristics were compared. All-cause mortality and risk of death were assessed using the adjusted hazard ratio (aHR).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Compared to controls, cases showed a higher 1-year mortality (34.8% vs. 45.2%) and mortality rate (0.46 vs. 0.69 deaths per person-year). Multivariable analysis showed significant risk of 1-year mortality in patients with bacteraemia (aHR: 1.31, 95% confidence interval [CI] 1.03–1.67), quick Sepsis Related Organ Failure Assessment (qSOFA) score of 2 or more (aHR: 2.71, 95% CI 2.05–3.57), and age of 90 years or older (aHR 1.53, 95% CI 1.17–1.99).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In elderly patients suspected of sepsis, bacteraemia is associated with a poor prognosis and higher long-term mortality. Other factors related to excess mortality were age over 90 years and a qSOFA score of 2 or more.</jats:p> </jats:sec>
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