Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

Medientyp: E-Artikel
Titel: Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
Beteiligte: Martin-Blondel, Guillaume; Lescure, François-Xavier; Assoumou, Lambert; Charpentier, Charlotte; Chapplain, Jean-Marc; Perpoint, Thomas; Grouteau, Gaspard; Cordel, Hugues; Pialoux, Gilles; Pacanowski, Jérome; Thy, Michael; Bauvois, Adeline; Laureillard, Didier; Hamrouni, Fadia; Algarte-Genin, Michèle; Poissy, Julien; Descamps, Diane; Costagliola, Dominique; Martin-Blondel, Guillaume; Delobel, Pierre; Grouteau, Gaspard; Le Henaff, Jean Roch; Mear, Vincent; Lagarrigues, Sandra; [...]
Erschienen: Springer Science and Business Media LLC, 2022
Erschienen in: BMC Infectious Diseases
Sprache: Englisch
DOI: 10.1186/s12879-022-07508-x
ISSN: 1471-2334
Schlagwörter: Infectious Diseases
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Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%—aOR = 1.33 95% CI [1.03–1.72]).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.</jats:p> </jats:sec>
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