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Kauffmann, Maëlis; Bobot, Mickaël; Daniel, Laurent; Torrents, Julia; Knefati, Yannick; Moranne, Olivier; Burtey, Stéphane; Zandotti, Christine; Jourde-Chiche, Noémie

Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy

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  • Medientyp: E-Artikel
  • Titel: Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy
  • Beteiligte: Kauffmann, Maëlis; Bobot, Mickaël; Daniel, Laurent; Torrents, Julia; Knefati, Yannick; Moranne, Olivier; Burtey, Stéphane; Zandotti, Christine; Jourde-Chiche, Noémie
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: BMC Nephrology
  • Sprache: Englisch
  • DOI: 10.1186/s12882-020-01911-9
  • ISSN: 1471-2369
  • Schlagwörter: Nephrology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The seroprevalence of human Parvovirus B19 (PVB19) is 70–85% in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We aimed to describe the cases of 4 patients with kidney injury related to PVB19 primary infection, and to evaluate the seroprevalence of PVB19 and the incidence of PVB19 primary infection in patients undergoing a native kidney biopsy.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Cases of PVB19 infection with kidney injury were reviewed from the archives of the department of Nephrology. A systematic screening of anti-PVB19 IgG and IgM antibodies and viral DNA was performed in sera from 100 consecutive patients with a kidney biopsy in 2017–2018.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The 4 patients with PVB19 infection-associated kidney disease displayed: one lupus-like glomerulonephritis (GN) without lupus auto-antibodies, one minimal change disease with tubular necrosis, one secondary hemolytic and uremic syndrome and one membrano-proliferative GN. In the 100 patients biopsied, 67 had elevated anti-PVB19 IgG, among whom 8 had elevated IgM, without circulating viral DNA, without any particular renal pathological pattern. One additional patient showed a seroconversion at the time of kidney biopsy, which revealed a class V lupus nephritis.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>PVB19 primary infection can be associated with different kidney diseases. The seroprevalence of PVB19 among patients with a kidney biopsy is similar to the overall population, and primary infection is rarely documented (1%) after systematic screening. Whether PV19 is nephrotoxic, or triggers renal endothelial injury and immune activation, remains to be elucidated.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang