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Sanges, Francesca; Floris, Matteo; Cossu-Rocca, Paolo; Muroni, Maria R.; Pira, Giovanna; Urru, Silvana Anna Maria; Barrocu, Renata; Gallus, Silvano; Bosetti, Cristina; D’Incalci, Maurizio; Manca, Alessandra; Uras, Maria Gabriela; Medda, Ricardo; Sollai, Elisabetta; Murgia, Alma; Palmas, Dolores; Atzori, Francesco; Zinellu, Angelo; Cambosu, Francesca; Moi, Tiziana; Ghiani, Massimo; Marras, Vincenzo; Santona, Maria Cristina; Canu, Luisa; [...]

Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

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  • Medientyp: E-Artikel
  • Titel: Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis
  • Beteiligte: Sanges, Francesca; Floris, Matteo; Cossu-Rocca, Paolo; Muroni, Maria R.; Pira, Giovanna; Urru, Silvana Anna Maria; Barrocu, Renata; Gallus, Silvano; Bosetti, Cristina; D’Incalci, Maurizio; Manca, Alessandra; Uras, Maria Gabriela; Medda, Ricardo; Sollai, Elisabetta; Murgia, Alma; Palmas, Dolores; Atzori, Francesco; Zinellu, Angelo; Cambosu, Francesca; Moi, Tiziana; Ghiani, Massimo; Marras, Vincenzo; Santona, Maria Cristina; Canu, Luisa; [...]
  • Erschienen: Springer Science and Business Media LLC, 2020
  • Erschienen in: BMC Cancer
  • Sprache: Englisch
  • DOI: 10.1186/s12885-020-06998-9
  • ISSN: 1471-2407
  • Schlagwörter: Cancer Research ; Genetics ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histologic variants, comparing “<jats:italic>special types</jats:italic>” to high-grade invasive breast carcinomas of no special type (IBC-NST).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This study was performed on data obtained from <jats:italic>TNBC Database,</jats:italic> including pathological features and clinical records of 1009 TNBCs patients diagnosed between 1994 and 2015 in the four most important Oncology Units located in different hospitals in Sardinia, Italy. Kaplan-Meier analysis, log-rank test and multivariate Cox proportional-hazards regression were applied for overall survival (OS) and disease free survival (DFS) according to TNBC histologic types.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>TNBC “<jats:italic>special types”</jats:italic> showed significant differences for several clinico-pathological features when compared to IBC-NST. We observed that in apocrine carcinomas as tumor size increased, the number of metastatic lymph nodes manifestly increased. Adenoid cystic carcinoma showed the smallest tumor size relative to IBC-NST. At five-year follow-up, OS was 92.1, 100.0, and 94.5% for patients with apocrine, adenoid cystic and medullary carcinoma, respectively; patients with lobular and metaplastic carcinoma showed the worst OS, with 79.7 and 84.3%, respectively. At ten-years, patients with adenoid cystic (100.0%) and medullary (94.5%) carcinoma showed a favourable prognosis, whereas patients with lobular carcinoma showed the worst prognosis (73.8%). TNBC medullary type was an independent prognostic factor for DFS compared to IBC-NST.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Our study confirms that an accurate and reliable histopathologic definition of TNBC subtypes has a significant clinical utility and is effective in the therapeutic decision-making process, with the aim to develop innovative and personalized treatments.</jats:p> </jats:sec>
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