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Nimptsch, Katharina; Aleksandrova, Krasimira; Fedirko, Veronika; Jenab, Mazda; Gunter, Marc J.; Siersema, Peter D.; Wu, Kana; Katzke, Verena; Kaaks, Rudolf; Panico, Salvatore; Palli, Domenico; May, Anne M; Sieri, Sabina; Bueno-de-Mesquita, Bas; Standahl, Karina; Sánchez, Maria-Jose; Perez-Cornago, Aurora; Olsen, Anja; Tjønneland, Anne; Bonet, Catalina Bonet; Dahm, Christina C.; Chirlaque, María-Dolores; Fiano, Valentina; Tumino, Rosario; [...]

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

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  • Medientyp: E-Artikel
  • Titel: Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
  • Beteiligte: Nimptsch, Katharina; Aleksandrova, Krasimira; Fedirko, Veronika; Jenab, Mazda; Gunter, Marc J.; Siersema, Peter D.; Wu, Kana; Katzke, Verena; Kaaks, Rudolf; Panico, Salvatore; Palli, Domenico; May, Anne M; Sieri, Sabina; Bueno-de-Mesquita, Bas; Standahl, Karina; Sánchez, Maria-Jose; Perez-Cornago, Aurora; Olsen, Anja; Tjønneland, Anne; Bonet, Catalina Bonet; Dahm, Christina C.; Chirlaque, María-Dolores; Fiano, Valentina; Tumino, Rosario; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: BMC Cancer
  • Sprache: Englisch
  • DOI: 10.1186/s12885-022-09778-9
  • ISSN: 1471-2407
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and <jats:italic>CRP</jats:italic> genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four <jats:italic>CRP</jats:italic> SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per <jats:italic>CRP</jats:italic>-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated <jats:italic>CRP</jats:italic> genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang