Beschreibung:
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>The evaluation of bone remodelling and dental root resorption can be performed by histological techniques or micro-computed tomography (micro-CT). The present study aimed to evaluate the relationship between these two procedures in the context of cleft repair in a rat model.</jats:p>
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<jats:title>Methods</jats:title>
<jats:p>The reconstructed maxillae and the orthodontically-moved first molar of 12 rats were analysed for correlations between the histological and radiological findings retrospectively. The alveolar cleft repairs were performed using bone autografts or (human) xenografts. Four weeks after the operation, the intervention of the first molar protraction was initiated and lasted for eight weeks. The newly formed bone and the root resorption lacunae were determined via histology. In the micro-CT analysis, the average change of bone mineral density (BMD), bone volume fraction (BV/TV), trabecular thickness and trabecular separation of the jaw, as well as the volume of the root resorptions were determined. The Pearson correlation coefficient was applied to study the associations between groups.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>Positive correlations were found only between the newly formed bone (histology) and BMD changes (micro-CT) in the autograft group (<jats:italic>r</jats:italic> = 0.812, 95% CI: 0.001 to 0.979, <jats:italic>p</jats:italic> = 0.05). The relationship of newly formed bone and BV/TV was similar but not statistically significant (<jats:italic>r</jats:italic> = 0.691, 95% CI: −0.274 to 0.963, <jats:italic>p</jats:italic> = 0.013). Regarding root resorption, no significant correlations were found.</jats:p>
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<jats:title>Conclusions</jats:title>
<jats:p>Due to the lack of correlation between histological and radiological findings of bone remodelling and the development of root resorptions, both methods should be combined in this cleft model in rats for a comprehensive analysis.</jats:p>
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