> Detailanzeige

Mazzarella, Ciro; Chiesa, Silvia; Toppi, Lucrezia; Hohaus, Stefan; Gaudino, Simona; D’Alo, Francesco; Dinapoli, Nicola; Davide, Resta; Zinicola, Tiziano; Bracci, Serena; Martino, Antonella; Beghella Bartoli, Francesco; Lepre, Elisabetta; Bertolini, Roberta; Mariani, Silvia; Colosimo, Cesare; Frascino, Vincenzo; Mattiucci, Gian Carlo; Gambacorta, Maria Antonietta; Valentini, Vincenzo; Balducci, Mario

May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?
  • Beteiligte: Mazzarella, Ciro; Chiesa, Silvia; Toppi, Lucrezia; Hohaus, Stefan; Gaudino, Simona; D’Alo, Francesco; Dinapoli, Nicola; Davide, Resta; Zinicola, Tiziano; Bracci, Serena; Martino, Antonella; Beghella Bartoli, Francesco; Lepre, Elisabetta; Bertolini, Roberta; Mariani, Silvia; Colosimo, Cesare; Frascino, Vincenzo; Mattiucci, Gian Carlo; Gambacorta, Maria Antonietta; Valentini, Vincenzo; Balducci, Mario
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Radiation Oncology, 18 (2023) 1
  • Sprache: Englisch
  • DOI: 10.1186/s13014-023-02251-2
  • ISSN: 1748-717X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract Purpose One of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment of neurocognitive functions (NCFs), which is mainly caused by radiation-induced injury to the hippocampus. With a view to preventing NCF impairment and personalizing treatment, we explored the feasibility of sparing the hippocampus during WBRT by correlating the sites of PCNSL lesions with the hippocampus. Methods and materials Pre-treatment MR images from patients who underwent WBRT between 2010 and January 2020—and post-radiotherapy images in cases of relapse—were imported into the Varian Eclipse treatment-planning system and registered with the simulation CT. We constructed three 3-dimensional envelopes around the hippocampus at distances of 5, 10 and 15 mm and also contoured primary lesions and recurrences. Results We analyzed 43 patients with 66 primary lesions: 9/66 (13.6%) involved the hippocampus and 11/66 (16.7%) were located within 5 mm of it. Thirty-six lesions (54.5%) were situated more than 15 mm from the hippocampus, while 10/66 (15.2%) were between 5 and 15 mm from it. The most common location was in deep brain structures (31%). Thirty-five of the 66 lesions relapsed: in field in 14/35 (40%) and outfield in 21/35 (60%) in different sites. Globally, 16/35 recurrences (45.7%) were located in the hippocampus or within 5 mm of it. Conclusion These data show that routinely sparing the hippocampus is not feasible. This approach could be considered in selected patients, when the lesion is more than 15 mm from the hippocampus.
  • Zugangsstatus: Freier Zugang