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Kast, Karin; John, Esther M.; Hopper, John L.; Andrieu, Nadine; Noguès, Catherine; Mouret-Fourme, Emmanuelle; Lasset, Christine; Fricker, Jean-Pierre; Berthet, Pascaline; Mari, Véronique; Salle, Lucie; Schmidt, Marjanka K.; Ausems, Margreet G. E. M.; Garcia, Encarnacion B. Gomez; van de Beek, Irma; Wevers, Marijke R.; Evans, D. Gareth; Tischkowitz, Marc; Lalloo, Fiona; Cook, Jackie; Izatt, Louise; Tripathi, Vishakha; Snape, Katie; Musgrave, Hannah; [...]

Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium

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  • Medientyp: E-Artikel
  • Titel: Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium
  • Beteiligte: Kast, Karin; John, Esther M.; Hopper, John L.; Andrieu, Nadine; Noguès, Catherine; Mouret-Fourme, Emmanuelle; Lasset, Christine; Fricker, Jean-Pierre; Berthet, Pascaline; Mari, Véronique; Salle, Lucie; Schmidt, Marjanka K.; Ausems, Margreet G. E. M.; Garcia, Encarnacion B. Gomez; van de Beek, Irma; Wevers, Marijke R.; Evans, D. Gareth; Tischkowitz, Marc; Lalloo, Fiona; Cook, Jackie; Izatt, Louise; Tripathi, Vishakha; Snape, Katie; Musgrave, Hannah; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Breast Cancer Research
  • Sprache: Englisch
  • DOI: 10.1186/s13058-023-01673-w
  • ISSN: 1465-542X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Introduction</jats:title> <jats:p>Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the <jats:italic>BRCA1</jats:italic> or <jats:italic>BRCA2</jats:italic> genes.</jats:p> </jats:sec><jats:sec> <jats:title>Patients and methods</jats:title> <jats:p>An international pooled cohort of 8091 <jats:italic>BRCA1/2</jats:italic> variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for <jats:italic>BRCA2</jats:italic> variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04–1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both <jats:italic>BRCA1</jats:italic> (HR 0.75 per 5 kg/m<jats:sup>2</jats:sup>, 95% CI 0.66–0.84) and <jats:italic>BRCA2</jats:italic> (HR 0.76, 95% CI 0.65–0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for <jats:italic>BRCA1</jats:italic> carriers (HR 1.20 per 5 kg/m<jats:sup>2</jats:sup>, 95% CI 1.02–1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01–1.19, respectively).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Anthropometric measures are associated with breast cancer risk for <jats:italic>BRCA1</jats:italic> and <jats:italic>BRCA2</jats:italic> variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.</jats:p> </jats:sec>
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