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Medientyp:
E-Artikel
Titel:
Post-translational modifications of PRC2: signals directing its activity
Beteiligte:
Yang, Yiqi;
Li, Gang
Erschienen:
Springer Science and Business Media LLC, 2020
Erschienen in:Epigenetics & Chromatin
Sprache:
Englisch
DOI:
10.1186/s13072-020-00369-1
ISSN:
1756-8935
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain.</jats:p>