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Benussi, Alberto; Premi, Enrico; Grassi, Mario; Alberici, Antonella; Cantoni, Valentina; Gazzina, Stefano; Archetti, Silvana; Gasparotti, Roberto; Fumagalli, Giorgio G.; Bouzigues, Arabella; Russell, Lucy L.; Samra, Kiran; Cash, David M.; Bocchetta, Martina; Todd, Emily G.; Convery, Rhian S.; Swift, Imogen; Sogorb-Esteve, Aitana; Heller, Carolin; van Swieten, John C.; Jiskoot, Lize C.; Seelaar, Harro; Sanchez-Valle, Raquel; Moreno, Fermin; [...]

Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

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  • Medientyp: E-Artikel
  • Titel: Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
  • Beteiligte: Benussi, Alberto; Premi, Enrico; Grassi, Mario; Alberici, Antonella; Cantoni, Valentina; Gazzina, Stefano; Archetti, Silvana; Gasparotti, Roberto; Fumagalli, Giorgio G.; Bouzigues, Arabella; Russell, Lucy L.; Samra, Kiran; Cash, David M.; Bocchetta, Martina; Todd, Emily G.; Convery, Rhian S.; Swift, Imogen; Sogorb-Esteve, Aitana; Heller, Carolin; van Swieten, John C.; Jiskoot, Lize C.; Seelaar, Harro; Sanchez-Valle, Raquel; Moreno, Fermin; [...]
  • Erschienen: Springer Science and Business Media LLC, 2024
  • Erschienen in: Alzheimer's Research & Therapy
  • Sprache: Englisch
  • DOI: 10.1186/s13195-024-01383-1
  • ISSN: 1758-9193
  • Schlagwörter: Cognitive Neuroscience ; Neurology (clinical) ; Neurology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (<jats:italic>p</jats:italic> &lt; 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (<jats:italic>p</jats:italic> &lt; 0.001). The addition of both markers further increased the AUC to 0.90 (<jats:italic>p</jats:italic> &lt; 0.001).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.</jats:p> </jats:sec>
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