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Benussi, Alberto;
Premi, Enrico;
Grassi, Mario;
Alberici, Antonella;
Cantoni, Valentina;
Gazzina, Stefano;
Archetti, Silvana;
Gasparotti, Roberto;
Fumagalli, Giorgio G.;
Bouzigues, Arabella;
Russell, Lucy L.;
Samra, Kiran;
Cash, David M.;
Bocchetta, Martina;
Todd, Emily G.;
Convery, Rhian S.;
Swift, Imogen;
Sogorb-Esteve, Aitana;
Heller, Carolin;
van Swieten, John C.;
Jiskoot, Lize C.;
Seelaar, Harro;
Sanchez-Valle, Raquel;
Moreno, Fermin;
[...]
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
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- Medientyp: E-Artikel
- Titel: Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
- Beteiligte: Benussi, Alberto; Premi, Enrico; Grassi, Mario; Alberici, Antonella; Cantoni, Valentina; Gazzina, Stefano; Archetti, Silvana; Gasparotti, Roberto; Fumagalli, Giorgio G.; Bouzigues, Arabella; Russell, Lucy L.; Samra, Kiran; Cash, David M.; Bocchetta, Martina; Todd, Emily G.; Convery, Rhian S.; Swift, Imogen; Sogorb-Esteve, Aitana; Heller, Carolin; van Swieten, John C.; Jiskoot, Lize C.; Seelaar, Harro; Sanchez-Valle, Raquel; Moreno, Fermin; [...]
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Erschienen:
Springer Science and Business Media LLC, 2024
- Erschienen in: Alzheimer's Research & Therapy, 16 (2024) 1
- Sprache: Englisch
- DOI: 10.1186/s13195-024-01383-1
- ISSN: 1758-9193
- Entstehung:
- Anmerkungen:
- Beschreibung: Abstract Background The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. Methods A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. Results The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). Conclusions The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.
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