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Medientyp:
E-Artikel
Titel:
Methane and Inflammation - A Review (Fight Fire with Fire)
Beteiligte:
Poles, Marietta Zita;
Juhász, László;
Boros, Mihály
Erschienen:
Springer Science and Business Media LLC, 2019
Erschienen in:
Intensive Care Medicine Experimental, 7 (2019) 1
Sprache:
Englisch
DOI:
10.1186/s40635-019-0278-6
ISSN:
2197-425X
Entstehung:
Anmerkungen:
Beschreibung:
AbstractMammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.