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Chen, Fuhuan; Chai, Jiake; Zhao, Jingyu; Wu, Jiang; Chen, Baoguo

Basic and clinical study of the effect of exogenous hyaluronic acid on the quality of acellular dermal matrix combined with thin intermediate split thickness skin graft

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  • Medientyp: E-Artikel
  • Titel: Basic and clinical study of the effect of exogenous hyaluronic acid on the quality of acellular dermal matrix combined with thin intermediate split thickness skin graft
  • Beteiligte: Chen, Fuhuan; Chai, Jiake; Zhao, Jingyu; Wu, Jiang; Chen, Baoguo
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: European Journal of Medical Research
  • Sprache: Englisch
  • DOI: 10.1186/s40001-023-01283-4
  • ISSN: 2047-783X
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>To promote wound recovery in the recipient region, we studied the impact of exogenous hyaluronic acid (HA) on acellular dermal matrix (ADM) paired with thin intermediate-thickness skin transplant.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This study contains animal and clinical experiments. 50 Japanese big ear rabbits were separated into HA1, HA2, PADM, TS, and NS groups. Clinical part included 50 scar patients dividing into 5 groups (TS + HA + ADM 1, TS + ADM2, TS, TS + ADM and normal skin (NS)).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>In the animal trial, after 56 days, the grafts contracted least in the HA2 group; HA2 had the highest microvascular density (MVD), HA concentration, and collagen I and III expression. In clinical work, ADM &gt; HA + ADM2 &gt; HA + ADM1 &gt; TS &gt; NS; Type I and III collagen: HA + ADM1 and HA + ADM2 were higher than ADM; HA content: TS &gt; HA + ADM1 &gt; HA + ADM 2 &gt; ADM.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>ADM, exogenous hyaluronic acid mixed with thin skin autograft has better biomechanical qualities and therapeutic impact than acellular dermal matrix alone, and the reconstructive result is near to self-thick skin autograft in all indexes.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang