Beschreibung:
<jats:p>The Patterson techniques, recently developed by the same authors for the<jats:italic>ab initio</jats:italic>crystal structure solution of proteins, have been applied to single and multiple anomalous diffraction (SAD and MAD) data to find the substructure of the anomalous scatterers. An automatic procedure has been applied to a large set of test structures, some of which were originally solved with remarkable difficulty. In all cases, the procedure automatically leads to interpretable electron density maps. Patterson techniques have been compared with direct methods; the former seem to be more efficient than the latter, so confirming the results obtained for<jats:italic>ab initio</jats:italic>phasing, and disproving the common belief that they could only be applied to determine large equal-atom substructures with difficulty.</jats:p>