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Wagner, Willi L.; Wuennemann, Felix; Pacilé, Serena; Albers, Jonas; Arfelli, Fulvia; Dreossi, Diego; Biederer, Jürgen; Konietzke, Philip; Stiller, Wolfram; Wielpütz, Mark O.; Accardo, Agostino; Confalonieri, Marco; Cova, Maria; Lotz, Joachim; Alves, Frauke; Kauczor, Hans-Ulrich; Tromba, Giuliana; Dullin, Christian

Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom

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  • Medientyp: E-Artikel
  • Titel: Towards synchrotron phase-contrast lung imaging in patients – a proof-of-concept study on porcine lungs in a human-scale chest phantom
  • Beteiligte: Wagner, Willi L.; Wuennemann, Felix; Pacilé, Serena; Albers, Jonas; Arfelli, Fulvia; Dreossi, Diego; Biederer, Jürgen; Konietzke, Philip; Stiller, Wolfram; Wielpütz, Mark O.; Accardo, Agostino; Confalonieri, Marco; Cova, Maria; Lotz, Joachim; Alves, Frauke; Kauczor, Hans-Ulrich; Tromba, Giuliana; Dullin, Christian
  • Erschienen: International Union of Crystallography (IUCr), 2018
  • Erschienen in: Journal of Synchrotron Radiation, 25 (2018) 6, Seite 1827-1832
  • Sprache: Nicht zu entscheiden
  • DOI: 10.1107/s1600577518013401
  • ISSN: 1600-5775
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: In-line free propagation phase-contrast synchrotron tomography of the lungs has been shown to provide superior image quality compared with attenuation-based computed tomography (CT) in small-animal studies. The present study was performed to prove the applicability on a human-patient scale using a chest phantom with ventilated fresh porcine lungs. Local areas of interest were imaged with a pixel size of 100 µm, yielding a high-resolution depiction of anatomical hallmarks of healthy lungs and artificial lung nodules. Details like fine spiculations into surrounding alveolar spaces were shown on a micrometre scale. Minor differences in artificial lung nodule density were detected by phase retrieval. Since we only applied a fraction of the X-ray dose used for clinical high-resolution CT scans, it is believed that this approach may become applicable to the detailed assessment of focal lung lesions in patients in the future.