Beschreibung:
<jats:title>Abstract</jats:title><jats:p>The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin‐6‐type cytokines. It is a member of the cytokine‐receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine‐binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three‐dimensional structure of the carboxy‐terminal domain of this region was determined by multidimensional NMR. The domain consists of seven β‐strands constituting a fibronectin type III‐like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.</jats:p>