Mubarak, Hanan A;
Mahmoud, Manal M;
Shoukry, Heba S;
Merzeban, Dina H;
Sayed, Safinaz S;
Rashed, Laila A
Protective effects of melatonin and glucagon‐like peptide‐1 receptor agonist (liraglutide) on gastric ischaemia–reperfusion injury in high‐fat/sucrose‐fed rats
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Protective effects of melatonin and glucagon‐like peptide‐1 receptor agonist (liraglutide) on gastric ischaemia–reperfusion injury in high‐fat/sucrose‐fed rats
Beteiligte:
Mubarak, Hanan A;
Mahmoud, Manal M;
Shoukry, Heba S;
Merzeban, Dina H;
Sayed, Safinaz S;
Rashed, Laila A
Erschienen:
Wiley, 2018
Erschienen in:
Clinical and Experimental Pharmacology and Physiology, 45 (2018) 9, Seite 934-942
Sprache:
Englisch
DOI:
10.1111/1440-1681.12956
ISSN:
0305-1870;
1440-1681
Entstehung:
Anmerkungen:
Beschreibung:
SummaryIschaemia–reperfusion (I–R) injury is a serious pathology that is often encountered with thrombotic events, during surgery when blood vessels are cross‐clamped, and in organs for transplantation. Increased oxidative stress is the main pathology in I–R injury, as assessed in studies on the heart, kidney, and brain with little data available on gastric I–R (GI–R). Liraglutide is aGLP‐1 receptor agonist that has insulinotropic and weight reducing actions, and melatonin that has been much studied as a chronotropic hormone; have also studied as being anti‐oxidative stress agents. Herein, we aimed to explore the effects of liraglutide and melatonin onGI–R injury with high‐fat/sucrose diet. Rats were divided into six groups; two diet‐control, two melatonin‐ and two liraglutide‐pretreated groups. All rats were subjected to 30 minutes of gastric ischaemia followed by 1 hour of reperfusion. Gastric tissues were assessed for the percentage ofDNAfragmentation, myeloperoxidase activity, total oxidant status, total antioxidant capacity, oxidative stress index,BMIand histopathological examination. We showed that high‐fat feeding for four weeks prior toGI–R significantly increasedBMI, oxidative stress indices and decreased total antioxidant capacity, with a neutral effect on apoptosis compared to controls. Pretreatment with either melatonin (10 mg/kg per day orally) or liraglutide (25 μg/kg per day ip) reverses these effects. Furthermore, both drugs reduced weight only inHFS‐fed rats. Both liraglutide and melatonin have nearly similar protective effects on gastric I–R injury through decreasing the oxidative stress and apoptosis.