Machiels, Melanie;
Wouterse, Sanne J;
Geijsen, Elisabeth D;
van Os, Rob M;
Bennink, Roel J;
van Laarhoven, Hanneke WM;
Hulshof, Maarten CCM
Distribution of lymph node metastases on FDG‐PET/CT in inoperable or unresectable oesophageal cancer patients and the impact on target volume definition in radiation therapy
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Medientyp:
E-Artikel
Titel:
Distribution of lymph node metastases on FDG‐PET/CT in inoperable or unresectable oesophageal cancer patients and the impact on target volume definition in radiation therapy
Beteiligte:
Machiels, Melanie;
Wouterse, Sanne J;
Geijsen, Elisabeth D;
van Os, Rob M;
Bennink, Roel J;
van Laarhoven, Hanneke WM;
Hulshof, Maarten CCM
Erschienen:
Wiley, 2016
Erschienen in:
Journal of Medical Imaging and Radiation Oncology, 60 (2016) 4, Seite 520-527
Beschreibung:
AbstractIntroductionDefinitive chemoradiotherapy (dCRT) is standard care for localised inoperable/unresectable oesophageal tumours. Many surgical series have reported on distribution of lymph node metastases (LNM) in resected patients. However, no data is available on the distribution of at‐risk LN regions in this more unfavourable patient group. This study aimed to determine the spread of LNM using FDG‐PET/CT, to compare it with the distribution in surgical series and to define its impact on the definition of elective LN irradiation (ENI).MethodsFDG‐PET/CT images of patients with oesophageal cancer treated with dCRT (from 2003 to 2013) were reviewed to identify the anatomic distribution of FDG‐avid LNs. Tumours were divided according to proximal, mid‐thoracic or distal localisation.ResultsAbout 105 consecutive patients entered analysis. The highest numbers of FDG‐avid LNs in proximal tumours were at LN station 101R (45%) and 106recL (35%). For mid‐thoracic tumours at 104R (30%) and 105 (30%). For tumours located in the distal oesophagus, the most common sites were along the lesser curvature of the stomach (21%) and the left gastric artery (21%). Except for the supraclavicular and pretracheal nodes, there were no positive locoregional LNM found outside the standard surgical resection area.ConclusionOur results show a good correlation between the distribution of nodal volumes at risk in surgical series and on FDG‐PET/CT. The results can be used to determine target definition in dCRT for oesophageal cancer. For mid‐thoracic tumours, the current target delineation guidelines may be extended based on the risk of node involvement, but more clinical studies are needed to determine if the potential harm of expanding the CTV outweighs the potential benefit.