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Fischer, Sebastian; Klockgether, Jens; Morán Losada, Patricia; Chouvarine, Philippe; Cramer, Nina; Davenport, Colin F.; Dethlefsen, Sarah; Dorda, Marie; Goesmann, Alexander; Hilker, Rolf; Mielke, Samira; Schönfelder, Torben; Suerbaum, Sebastian; Türk, Oliver; Woltemate, Sabrina; Wiehlmann, Lutz; Tümmler, Burkhard

Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14

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  • Medientyp: E-Artikel
  • Titel: Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14
  • Beteiligte: Fischer, Sebastian; Klockgether, Jens; Morán Losada, Patricia; Chouvarine, Philippe; Cramer, Nina; Davenport, Colin F.; Dethlefsen, Sarah; Dorda, Marie; Goesmann, Alexander; Hilker, Rolf; Mielke, Samira; Schönfelder, Torben; Suerbaum, Sebastian; Türk, Oliver; Woltemate, Sabrina; Wiehlmann, Lutz; Tümmler, Burkhard
  • Erschienen: Wiley, 2016
  • Erschienen in: Environmental Microbiology Reports
  • Sprache: Englisch
  • DOI: 10.1111/1758-2229.12372
  • ISSN: 1758-2229
  • Schlagwörter: Agricultural and Biological Sciences (miscellaneous) ; Ecology, Evolution, Behavior and Systematics
  • Entstehung:
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  • Beschreibung: <jats:title>Summary</jats:title><jats:p>Bacterial populations differentiate at the subspecies level into clonal complexes. Intraclonal genome diversity was studied in 100 isolates of the two dominant <jats:styled-content style="fixed-case"><jats:italic>P</jats:italic></jats:styled-content><jats:italic>seudomonas aeruginosa</jats:italic> clones <jats:styled-content style="fixed-case">C</jats:styled-content> and <jats:styled-content style="fixed-case">PA</jats:styled-content>14 collected from the inanimate environment, acute and chronic infections. The core genome was highly conserved among clone members with a median pairwise within‐clone single nucleotide sequence diversity of 8 × 10<jats:sup>−6</jats:sup> for clone <jats:styled-content style="fixed-case">C</jats:styled-content> and 2 × 10<jats:sup>−5</jats:sup> for clone <jats:styled-content style="fixed-case">PA</jats:styled-content>14. The composition of the accessory genome was, on the other hand, as variable within the clone as between unrelated clones. Each strain carried a large cargo of unique genes. The two dominant worldwide distributed <jats:styled-content style="fixed-case"><jats:italic>P</jats:italic></jats:styled-content>. <jats:italic>aeruginosa</jats:italic> clones combine an almost invariant core with the flexible gain and loss of genetic elements that spread by horizontal transfer.</jats:p>